# Focused Medical frontier hair status check — October 3, 2026

[Home](../README.md) · [Hair notes](../topics/19_hair_loss.md) · [Research log](README.md)

## Scope and source verification

Focused primary-source verification while implementing the Medical frontier visualization. This is not the Tuesday/Friday scheduled watch and not a completed 28-topic monitoring run. The broad review date, all full-topic successful-check timestamps and unrelated state remain unchanged.

- **PP405 / AWAKEN / NCT07819435:** Retrieved the original API. Last posted **October 2, 2026**; **RECRUITING**; registered Phase 2/3; **actual study start September 21, 2026**; 600 planned participants. Primary completion December 2027 and final completion June 2028 remain estimates. No posted efficacy results. Registry study-start metadata is not an independently verified first-dose announcement. [Original record](https://clinicaltrials.gov/study/NCT07819435); [API](https://clinicaltrials.gov/api/v2/studies/NCT07819435).
- **ABS-201 / HEADLINE / NCT07317544:** Retrieved original API. Last posted September 3, 2026; recruiting; structured Phase 1/2 while official title says Phase 1 first-in-human. Existing sponsor human evidence is early Phase 1 safety. This is metadata precision, not a new result or standalone alert. [Original API](https://clinicaltrials.gov/api/v2/studies/NCT07317544).

## Recovered historical baseline

The liver note also adds Altimmune’s **August 3, 2026** PERFORMA Phase 3 enrollment announcement, recovered while checking stage placement. This is historical context, not a new October efficacy result or a complete liver-topic review. [Dated sponsor release](https://rss.globenewswire.com/news-release/2026/08/03/3337439/0/en/altimmune-initiates-performa-phase-3-trial-of-pemvidutide-in-patients-with-mash.html).

## Informal claim follow-up

Reopened the saved [r/tressless PP405 thread](https://www.reddit.com/r/tressless/comments/1wh8oo6/pelage_pharmaceuticals_phase_3_trials_for_pp405/) by roystreetcoffee. It interprets registry/secondary information as a September start. Relative timestamps on the retrieved page do not establish an exact original post date; saved earlier monitoring also referred to secondhand August-email comments. Current official recruitment and the reported September start partly corroborate broad commencement. Original-email authenticity, earlier August timing and specific individual enrollment/dosing claims remain unconfirmed. Rumor key **pp405_september2026_recruitment_rumor** changes from saved unconfirmed status to **corroborated but unconfirmed in part** on October 3; the official registry event has its own key.

## Coverage for the active watchlist

| Topic | Coverage in this focused addition |
| --- | --- |
| whole_body_mri | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| galleri | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| glp1 | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| muscle | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| longevity | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| localized_fat | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| cardiovascular | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| alzheimers | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| psychedelics | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| ssri_antidepressants | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| joint_preservation | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| sleep | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| liver | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| cancer_vaccines | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| autoimmune | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| pain | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| kidney | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| hearing_vision | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| hair_loss | AWAKEN/HEADLINE registry verification and saved PP405 rumor follow-up only; broader hair/alopecia/graying coverage incomplete. |
| skin_aging | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| scars | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| facial_volume | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| pigmentation | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| acne_rosacea | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| dental | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| allergy_airway | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| infectious_disease | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |
| genetic_screening | Not rechecked in this focused addition; prior coverage dates and gaps preserved. |

## Remaining gaps and next check

No comprehensive hair pipeline, regulator, adverse-event, worldwide registry or rumor discovery sweep. Other programs retain the existing coverage gaps. PP405 results, visible benefit, durability and long-term safety remain unanswered; estimated completion is not an announced result date. Do not repeat the same recruiting update as a new alert on the next run.

## Saved-file verification and state

The topic note, current landscape, calendar, latest feed, cover-page preview and log index were read back together; original history were retained. State updates only the hair topic’s focused-check metadata, appends a stable registry event and a separately labeled rumor-status record. Global last_run_utc, all last_successful_check_utc values and website_publication are preserved. Website publication is handled separately by the parent release workflow.