@font-face{font-family:'DM Sans';font-style:normal;font-weight:400 700;font-display:swap;src:url('/fonts/dm-sans-normal-latin.woff2') format('woff2')}
@font-face{font-family:'Instrument Serif';font-style:normal;font-weight:400;font-display:swap;src:url('/fonts/instrument-serif-normal-latin.woff2') format('woff2')}
@font-face{font-family:'Instrument Serif';font-style:italic;font-weight:400;font-display:swap;src:url('/fonts/instrument-serif-italic-latin.woff2') format('woff2')}
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b{font-weight:500;color:var(--ink)}.section-heading{display:flex;justify-content:space-between;align-items:center;gap:14px;margin:32px 0 17px}.section-heading h2{margin:0}.text-link{font-size:.875rem;color:var(--blue);display:inline-flex;align-items:center;gap:8px}.text-link:hover{text-decoration:underline}.text-link svg{width:17px;height:17px}.feature-grid{display:grid;grid-template-columns:1.52fr 1fr;gap:20px}.feature{border-radius:var(--radius);overflow:hidden;background:var(--blue-deep);color:#fff;position:relative;min-height:350px;display:flex;flex-direction:column;padding:28px 30px}.feature .eyebrow{color:#a8c4ff;display:flex;gap:9px;align-items:center}.feature h2{font-family:'Instrument Serif',Georgia,serif;font-size:2.35rem;line-height:1.1;margin:20px 0 10px;letter-spacing:0;max-width:360px;font-weight:400}.feature p{color:#c3d2ef;font-size:.9375rem;max-width:370px;margin-bottom:20px}.feature .text-link{color:white;margin-top:auto}.feature-divider{position:absolute;right:8%;top:60px;bottom:70px;width:1px;background:#4161a2;transform:rotate(24deg);opacity:.6}.feature-mark{display:flex;gap:13px;align-items:center;font-size:.75rem;letter-spacing:.07em;color:#b5c9ec}.light-panel{background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:26px}.light-panel h2{font-size:1.3rem;margin-bottom:24px}.event-preview{display:grid;grid-template-columns:48px 1fr;gap:15px;padding:15px 0;border-bottom:1px solid var(--line)}.event-preview:first-of-type{padding-top:0}.event-preview:last-of-type{border-bottom:0}.date-block{color:var(--blue);text-align:center;line-height:1.2;display:flex;flex-direction:column}.date-block b{font-family:'Instrument Serif',Georgia,serif;font-size:1.9rem;font-weight:400}.date-block small{font-size:.625rem;text-transform:uppercase;letter-spacing:.1em;margin-bottom:3px}.event-preview h3{font-size:.925rem;line-height:1.4;margin:1px 0 5px}.event-preview p{font-size:.8rem;color:var(--muted);margin:0}.pill{display:inline-flex;align-items:center;gap:5px;font-size:.75rem;line-height:1.5;font-weight:550;border-radius:5px;padding:3px 8px;background:var(--soft);color:var(--blue)}.pill.amber{background:#fcf1dc;color:var(--amber)}.pill.teal{background:#e8f4f1;color:var(--teal)}.pill.gray{background:#eff1f5;color:#647186}.topic-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}.topic-card{padding:24px;background:white;border:1px solid var(--line);border-radius:12px;transition:transform .2s,border-color .2s;display:flex;flex-direction:column;min-height:188px}.topic-card:hover{transform:translateY(-3px);border-color:#9cb5e5}.topic-card .eyebrow{color:var(--muted);font-size:.6875rem;letter-spacing:.08em;margin-bottom:24px}.topic-card h3{font-size:1.17rem;line-height:1.35;margin-bottom:9px;letter-spacing:normal}.topic-card p{font-size:.875rem;line-height:1.55;color:var(--muted);margin-bottom:20px}.card-footer{margin-top:auto;display:flex;justify-content:space-between;align-items:center;font-size:.8rem;color:var(--blue)}.card-footer svg{width:18px}.blue-number{color:var(--blue);font-family:'Instrument Serif',Georgia,serif;font-size:1.7rem;font-weight:400}.footer{border-top:1px solid var(--line);padding-top:22px;margin-top:42px;display:flex;justify-content:space-between;gap:20px;color:var(--muted);font-size:.8rem}.mobile-menu{display:none}.empty{padding:50px;text-align:center;border:1px dashed var(--line);border-radius:12px}.loading-line{height:3px;background:var(--blue);position:fixed;top:0;left:0;right:0;z-index:100}.preview-chart{display:flex;align-items:end;gap:10px;height:80px;width:170px;margin:20px 0}.preview-chart i{height:var(--h);flex:1;border-top:2px solid #92b7ff;background:linear-gradient(#4473d6,#244b97);border-radius:3px 3px 0 0}.mini-note{font-size:.75rem;color:#aebfe0}.feature-links{display:flex;gap:20px}.section-copy{color:var(--muted);max-width:760px;font-size:1rem}.badge-line{display:flex;align-items:center;gap:8px;flex-wrap:wrap}
@media(min-width:1600px){.main{padding-top:48px}.feature{min-height:375px}}@media(max-width:1150px){.shell{grid-template-columns:210px minmax(0,1fr)}.sidebar{padding:28px 15px}.main{padding:30px 28px 55px}.feature-grid{grid-template-columns:1.2fr 1fr}.feature{padding:24px}.topic-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.snapshot{display:none}h1{font-size:3.1rem}}@media(max-width:800px){.shell{display:block}.sidebar{display:none;position:fixed;z-index:50;width:260px;box-shadow:10px 0 60px #12263f33}.sidebar.open{display:flex}.mobile-menu{display:block;background:none;border:0;padding:4px}.mobile-menu svg{width:22px;height:22px}.breadcrumbs{display:none}.search-box{width:100%}.main{padding:26px 20px 45px}.feature-grid{grid-template-columns:1fr}.feature{min-height:310px}.topic-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}.topic-card{padding:19px}.feature-divider{display:none}.footer{flex-direction:column;gap:10px}.overview-intro h1{font-size:2.8rem}.section-heading h2{font-size:1.3rem}.section-heading{align-items:baseline}}@media(max-width:480px){.topic-grid{grid-template-columns:1fr}.search-box kbd{display:none}.feature h2{font-size:2.2rem}.main{padding:25px 17px 40px}.light-panel{padding:23px}.topic-card{min-height:150px}.topic-card .eyebrow{margin-bottom:17px}}
@media(prefers-reduced-motion:reduce){*{animation:none!important;transition:none!important;scroll-behavior:auto!important}}

/* Evidence-led reading surfaces */
.eyebrow svg{width:17px;height:17px}.evidence-feature{background:linear-gradient(120deg,#10327f,#123e9b);min-height:397px}.evidence-feature h2{font-size:2.65rem;margin:18px 0 12px;max-width:none}.evidence-feature h2 em{font-weight:400;color:#b6ceff}.evidence-feature p{max-width:520px;margin-bottom:16px}.mini-comparison{padding:8px 0 21px}.mini-row{display:grid;grid-template-columns:145px 1fr 64px;align-items:center;gap:12px;margin:14px 0;font-size:.8125rem;color:#d0ddf7}.mini-track{height:12px;background:#ffffff0a;border-right:1px solid #8099cf66}.mini-track i{display:block;height:100%;background:#a5c4ff;border-radius:2px}.mini-track i.control{background:#5476b8}.mini-row b{color:white;font-size:1.18rem;font-weight:500;text-align:right;font-variant-numeric:tabular-nums}.mini-row b small{font-size:.75rem;color:#bacbea}.mini-caption{font-size:.75rem;color:#b0c5ea;margin-top:16px}.feature-bottom{display:flex;align-items:center;justify-content:space-between;gap:20px;border-top:1px solid #ffffff25;padding-top:17px;margin-top:auto;font-size:.75rem;color:#b8ccec}.feature-bottom .text-link{margin:0;font-size:.8125rem;white-space:nowrap}.news-strip{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));border:1px solid var(--line);background:white;border-radius:12px;overflow:hidden}.news-item{padding:22px 25px;border-right:1px solid var(--line);transition:background .2s}.news-item:last-child{border-right:0}.news-item:hover{background:#f8faff}.news-meta{font-size:.75rem;color:var(--muted);line-height:1.4;display:flex;gap:7px;flex-wrap:wrap}.news-item h3{font-size:1rem;font-weight:550;line-height:1.55;margin:12px 0 20px}.news-bottom{display:flex;gap:10px;justify-content:space-between;align-items:center}.news-bottom svg{width:17px;height:17px;color:var(--blue);flex:none}.library-controls{display:grid;grid-template-columns:1fr 260px;gap:20px;margin:30px 0 20px}.library-search{display:flex;align-items:center;gap:13px;border:1px solid var(--line);border-radius:9px;padding:15px 18px;background:white}.library-search svg{width:19px;color:var(--muted);flex:none}.library-search input{width:100%;border:0;outline:0;font-size:1rem;background:transparent}.library-search:focus-within{outline:2px solid #b9ccff}.select-wrap{display:flex;flex-direction:column;gap:5px;min-width:0}.select-wrap>span{font-size:.75rem;color:var(--muted)}.select-wrap select{width:100%;background:white;color:var(--ink);border:1px solid var(--line);border-radius:8px;padding:10px 12px;font-size:.875rem}.filter-row{display:flex;flex-wrap:wrap;gap:8px;margin-bottom:25px}.filter-chip{border:1px solid var(--line);background:white;color:#5b6980;border-radius:7px;padding:9px 12px;font-size:.875rem;line-height:1.5}.filter-chip:hover{border-color:#92a9d8;color:var(--blue)}.filter-chip.selected{color:white;background:var(--blue);border-color:var(--blue)}.filter-chip span{font-size:.75rem;margin-left:5px;opacity:.7}.results-heading{display:flex;justify-content:space-between;gap:12px;align-items:center;color:var(--muted);font-size:.875rem;margin:24px 0 16px}.plain-button{background:none;border:0;color:var(--blue);padding:0;font-size:.875rem}.plain-button:hover{text-decoration:underline}.library-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.library-card h3{font-family:'Instrument Serif',Georgia,serif;font-size:1.8rem;line-height:1.18;font-weight:400}.library-card .eyebrow{margin-bottom:17px}.library-card p{font-size:.9375rem;line-height:1.65}.card-next{font-size:.8125rem;color:#61708a;line-height:1.55;background:#f6f8fc;padding:13px 15px;margin-top:auto;margin-bottom:20px;border-radius:7px}.card-next span{display:block;color:#3f5271;font-weight:600;margin-bottom:6px;font-size:.6875rem;text-transform:uppercase;letter-spacing:.08em}.library-card .card-footer{margin-top:0}.topic-topline{display:flex;justify-content:space-between;gap:20px;margin-bottom:30px;font-size:.8rem}.topic-header{max-width:930px}.topic-header .eyebrow{color:var(--muted)}.topic-header h1{font-size:3.4rem;margin-top:14px;max-width:900px}.topic-deck{font-size:1.15rem;line-height:1.7;color:#566781;max-width:810px;margin-bottom:20px}.page-nav{display:flex;flex-wrap:wrap;gap:29px;padding:24px 0 17px;margin-top:16px;border-bottom:1px solid var(--line);font-size:.875rem;color:#566680}.page-nav a:hover{color:var(--blue)}.topic-layout{display:grid;grid-template-columns:minmax(0,1fr) 275px;gap:38px;margin-top:20px}.topic-main{min-width:0}.brief-section{padding:25px 0;scroll-margin-top:25px}.brief-section>.eyebrow{color:var(--blue);margin-bottom:13px}.brief-section h2{font-family:'Instrument Serif',Georgia,serif;font-size:2rem;line-height:1.2;letter-spacing:0;font-weight:400}.brief-section>.section-heading{margin:0 0 25px}.prose{font-size:1.0625rem;line-height:1.8;color:#36465f;overflow-wrap:anywhere}.prose p{line-height:1.85;margin-bottom:22px}.prose a{color:var(--blue);text-decoration:underline;text-decoration-color:#b3c5e9;text-underline-offset:3px}.prose a:hover{text-decoration-color:var(--blue)}.prose strong{font-weight:650;color:#233651}.prose h1{font-size:3rem;color:var(--ink);margin-bottom:24px}.prose h2{font-family:'Instrument Serif',Georgia,serif;font-size:2.2rem;color:var(--ink);margin:40px 0 18px;line-height:1.15;font-weight:400}.prose h3{font-size:1.35rem;color:var(--ink);font-weight:550;line-height:1.4;margin:37px 0 16px}.prose h4{font-size:1.1rem;font-weight:650;color:#243955;line-height:1.5;margin:29px 0 14px}.prose h5{font-size:1rem;font-weight:650;line-height:1.5}.prose ul,.prose ol{padding-left:24px;line-height:1.8;margin:15px 0 25px}.prose li{margin:12px 0;padding-left:3px}.prose blockquote{border-left:3px solid #799cea;background:var(--soft);margin:25px 0;padding:18px 23px}.prose code{font-size:.9em;background:#edf1f8;padding:2px 5px;border-radius:4px}.prose hr{border:0;border-top:1px solid var(--line);margin:30px 0}.prose.compact{font-size:1rem}.prose.compact li{margin:12px 0}.table-scroll{overflow-x:auto;max-width:100%;border:1px solid var(--line);border-radius:8px;margin:25px 0;background:white;overscroll-behavior-inline:contain}table{border-collapse:collapse;width:100%;font-size:.875rem;line-height:1.6;text-align:left}th{padding:14px 16px;background:#eef3fb;color:#344967;font-weight:600;vertical-align:top}td{padding:16px;vertical-align:top;border-top:1px solid var(--line);min-width:145px}td p{margin:0!important}.topic-rail{padding-top:28px;min-width:0}.rail-card{border:1px solid var(--line);background:white;border-radius:12px;padding:24px;margin-bottom:24px}.rail-card .eyebrow{color:var(--blue);font-size:.7rem}.rail-card h3{font-size:1.2rem;line-height:1.3;margin:15px 0 12px}.rail-card p{font-size:.875rem;line-height:1.75;color:#66758b}.rail-card .text-link{font-size:.8125rem}.rail-card.plain{border:0;background:transparent;padding:10px 8px}.rail-card.plain p{font-size:.875rem;line-height:1.8}.rail-milestones{border-top:1px solid var(--line);margin:18px 0}.rail-milestones a{display:flex;flex-direction:column;gap:4px;padding:13px 0;border-bottom:1px solid var(--line)}.rail-milestones span{font-size:.875rem;font-weight:500;color:#3c5b91}.rail-milestones small{font-size:.75rem;color:var(--muted)}.related-link{display:flex;align-items:center;justify-content:space-between;gap:10px;padding:13px 0;font-size:.875rem;line-height:1.5;border-bottom:1px solid var(--line);color:#536681}.related-link svg{width:15px;flex:none}.raw-link{font-size:.75rem;padding:5px 8px}.inline-feature{display:flex;align-items:center;gap:18px;padding:22px;background:#eaf0fd;border:1px solid #d4dff7;border-radius:12px;margin:15px 0 30px}.inline-feature .feature-icon{width:42px;height:42px;display:grid;place-items:center;border:1px solid #c7d5f5;border-radius:50%;color:var(--blue);flex:none}.feature-icon svg{width:20px}.inline-feature .eyebrow{color:var(--blue);font-size:.6875rem}.inline-feature h3{font-family:'Instrument Serif',Georgia,serif;font-size:1.6rem;margin:8px 0;font-weight:400}.inline-feature p{color:#657490;font-size:.875rem;margin:0}.inline-feature>svg{width:22px;flex:none;margin-left:auto;color:var(--blue)}details summary{cursor:pointer;font-weight:550;display:flex;align-items:center;justify-content:space-between;gap:20px;padding:17px 0;color:var(--ink);font-size:1rem}summary::-webkit-details-marker{display:none}summary:after{content:'+';font-size:1.35rem;color:var(--blue);font-weight:400}details[open]>summary:after{content:'−'}summary>span:nth-child(2){font-size:.8rem;color:var(--muted);font-weight:400;margin-left:auto}summary>svg{width:18px;margin-left:auto}.source-list{list-style:none;padding:0;margin:15px 0}.source-list li{border-top:1px solid var(--line)}.source-list a{display:grid;grid-template-columns:1fr 22px;column-gap:18px;padding:14px 0;font-size:.875rem;line-height:1.6;color:var(--blue)}.source-list small{display:block;font-size:.75rem;color:var(--muted);grid-column:1;overflow-wrap:anywhere}.source-list svg{width:17px;grid-column:2;grid-row:1/3;align-self:center}.rumor-section{background:#fff9ee;border:1px solid #e9d9bb;border-radius:12px;padding:27px;margin:25px 0;scroll-margin-top:25px}.rumor-section h2{font-family:'Instrument Serif',Georgia,serif;font-size:2.05rem;margin:18px 0 13px;font-weight:400}.rumor-section>p{color:#7d694c;font-size:.9375rem}.rumor-section .prose{font-size:1rem}.personal-notes{padding:28px;background:#fff;border-left:3px solid #a5badd;margin-top:25px}.personal-notes>.eyebrow{color:var(--muted)}.personal-notes .prose{margin-top:13px;font-size:1rem}.personal-notes .prose 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@media(max-width:580px){h1{font-size:2.8rem}.library-controls{grid-template-columns:1fr;gap:15px}.library-grid{grid-template-columns:1fr}.library-card{padding:25px}.library-card h3{font-size:1.9rem}.filter-row{gap:7px}.filter-chip{font-size:.8125rem;padding:8px 10px}.news-item{display:block}.news-bottom{margin-top:16px}.news-item h3{font-size:1.0625rem}.feature-bottom{flex-direction:column;align-items:flex-start}.evidence-feature h2{font-size:2.55rem}.mini-row{grid-template-columns:110px 1fr 59px;font-size:.75rem}.mini-row b{font-size:1rem}.mini-caption{font-size:.6875rem;line-height:1.6}.feature p{font-size:.9375rem}.feature{padding:25px}.rail-milestones{display:block}.rail-milestones a{padding:12px 0;border-bottom:1px solid var(--line)}.rail-milestones a:last-child{border:0}.topic-rail{display:block}.topic-header h1{font-size:2.55rem}.topic-deck{font-size:1.0625rem}.prose{font-size:1rem}.prose h3{font-size:1.25rem}.prose h4{font-size:1.0625rem}.prose li{padding:0}.prose ul,.prose ol{padding-left:21px}.brief-section>.section-heading{align-items:flex-start;flex-direction:column;gap:15px}.inline-feature{padding:20px;gap:13px}.inline-feature .feature-icon{display:none}.inline-feature h3{font-size:1.6rem}.inline-feature .eyebrow{font-size:.625rem}.calendar-top{flex-direction:column;gap:15px}.calendar-top .select-wrap{width:100%}.calendar-stat{max-width:none}.calendar-legend{gap:15px;font-size:.75rem;margin-bottom:25px}.milestone-list{padding:0 20px}.milestone{grid-template-columns:1fr 17px;gap:12px}.milestone-date{grid-column:1/-1;font-size:.875rem}.milestone-body{grid-column:1}.milestone>svg{grid-column:2}.milestone h3{font-size:.9375rem}.milestone .badge-line{align-items:flex-start;flex-direction:column;gap:8px}.chart-controls{padding:18px;gap:18px}.study-selector{width:100%}.study-button{flex:1}.metric-controls{width:100%;justify-content:space-between}.metric-button{padding:9px 10px;flex:1}.chart-main{padding:25px 18px}.study-context{padding:25px 20px}.study-context dl{columns:1}.chart-heading p{font-size:.75rem}.chart-annotation{font-size:.75rem}.chart-takeaway{padding:16px;font-size:.875rem}.chart-viewport{margin-right:-8px}.timeline-tab{padding:17px 18px;font-size:.8125rem;line-height:1.5;flex:1;text-align:left}.timeline-intro{padding:25px 22px 5px}.timeline-intro h3{font-size:1.8rem}.timeline-intro p{font-size:.875rem}.journey-detail{display:block;padding:25px 22px}.journey-index{font-size:2.5rem;margin-bottom:20px}.journey-index>span{display:inline-block;margin:0 0 0 8px}.journey-copy h3{font-size:1.8rem}.journey-copy p{font-size:.9375rem}.journey-controls{padding:20px 18px;gap:10px}.journey-controls>span{display:none}.journey-controls button{font-size:.8125rem;padding:10px 14px}.diagram-heading{padding:28px 24px 10px}.diagram-heading h3{font-size:1.9rem}.evidence-path{padding:15px 22px 25px}.evidence-node{padding:20px;grid-template-columns:1fr}.evidence-node h4{margin:15px 0 10px}.evidence-node p,.node-caption{grid-column:1}.diagram-branches{padding:0 25px 25px}.rumor-section{padding:22px}.personal-notes{padding:23px}.source-list small{font-size:.75rem}.principle-grid article{padding:25px;display:block}.principle-grid h2{margin:17px 0 13px}.methodology-copy{font-size:1rem}.document-prose h1{font-size:2.5rem}.informal-preview{padding:24px}.calendar-section>h2{font-size:1.8rem}.section-heading .text-link{font-size:.8125rem}.section-heading h2{font-size:1.25rem}}
@media print{.sidebar,.topbar,.page-nav,.topic-rail,.footer,.visual-jump,.chart-controls,.journey-controls{display:none!important}.shell{display:block}.main{padding:0;max-width:none}.topic-layout{display:block}.topic-main .prose{max-width:none}a{color:inherit}details{display:block}.feature{color:#111;background:#fff;border:1px solid #ddd}.prose,.prose p{color:#111}.table-scroll{overflow:visible}body{background:#fff}}
.dynamic-event{grid-template-columns:85px 1fr;gap:16px;padding:18px 0}.event-date-text{font-size:.875rem;line-height:1.5;font-weight:500;color:var(--blue)}.dynamic-event h3{font-size:.9375rem;line-height:1.6}.dynamic-event p{font-size:.75rem;line-height:1.6}.metric-button,.feature-bottom .text-link,.journey-date,.timeline-tab,.study-context .text-link{font-size:.8755rem}.mini-row{font-size:.875rem;line-height:1.45}.chart-heading p{font-size:.875rem}.calendar-legend{line-height:1.8}.journey-stop small{font-size:.75rem}.page-nav{font-size:.875rem}
@media(max-width:580px){.dynamic-event{grid-template-columns:82px 1fr;gap:12px}.mini-row{grid-template-columns:125px 1fr 58px}.mini-row span{line-height:1.4}.metric-button{padding:9px 8px}.feature-bottom .text-link{white-space:normal}.chart-heading p{font-size:.8125rem}.sidebar-foot{padding-bottom:20px}}

/* Typography and navigation refinement */
:root{font-kerning:normal;font-optical-sizing:auto}
.brand{letter-spacing:normal}
.nav-link{transition:background-color 150ms ease,color 150ms ease}
.main:focus{outline:none}
@media(prefers-reduced-motion:reduce){.nav-link{transition:none}}

/* Research areas belong to the library, with ordinary text links and explicit hierarchy. */
.main-nav-list,.library-subnav{list-style:none;padding:0;margin:0}
.main-nav-list>li{margin-bottom:5px}
.library-subnav{margin:5px 0 14px 34px;padding:2px 0 2px 11px;border-left:1px solid var(--line)}
.library-subnav .group-link{display:block;padding:9px 10px;font-size:.875rem;line-height:1.5;transition:background-color 150ms ease,color 150ms ease}
.library-subnav .group-link.active{background:var(--soft);color:var(--blue);font-weight:600}
.library-subnav .group-link.ancestor,.nav-link.ancestor{color:#345585;font-weight:600}
.sidebar{overflow-y:auto;overscroll-behavior:contain}
.sidebar>nav,.sidebar>.brand{flex-shrink:0}
@media(prefers-reduced-motion:reduce){.library-subnav .group-link{transition:none}}

/* A quieter reading surface: one title, compact cards, optional navigation. */
.shell{--sidebar-width:246px;grid-template-columns:var(--sidebar-width) minmax(0,1fr);transition:grid-template-columns 180ms ease}
.shell.sidebar-collapsed{grid-template-columns:0 minmax(0,1fr)}
.sidebar{width:var(--sidebar-width);min-width:0;opacity:1;visibility:visible;transition:opacity 140ms ease,visibility 0s}
.shell.sidebar-collapsed .sidebar{opacity:0;visibility:hidden;transition:opacity 140ms ease,visibility 0s 180ms}
.sidebar-heading{display:flex;align-items:center;justify-content:space-between;gap:10px;flex-shrink:0}
.sidebar-heading .brand{margin:0}
.menu-toggle{display:inline-flex;align-items:center;gap:9px;padding:10px 8px;margin-left:-8px;border:0;border-radius:6px;background:transparent;font-size:.875rem;color:var(--muted);flex:none}
.menu-toggle:hover,.library-toggle:hover,.navigation-close:hover{background:var(--paper);color:var(--ink)}
.menu-toggle svg{width:19px;height:19px}
.navigation-close{display:none}
.navigation-backdrop{display:none}

.search-box{width:340px;background:rgba(255,255,255,.7)}
.main{max-width:1340px;padding-top:25px}
.main>h1,.page-heading h1,.overview-intro h1{font-size:clamp(2.5rem,4vw,3.15rem);line-height:1.12;margin:0}
.page-heading{margin-bottom:28px}
.overview-intro{align-items:center;margin-bottom:30px}
.overview-intro h1{margin:0}
.snapshot{font-size:.8125rem}
.library-nav-row{display:flex;align-items:center;gap:3px}
.library-nav-row .nav-link{flex:1;min-width:0;margin:0}
.library-toggle{display:grid;place-items:center;flex:none;width:34px;height:40px;background:transparent;border:0;border-radius:6px;color:var(--muted)}
.library-toggle svg{width:15px;height:15px;transition:transform 180ms ease}
.library-toggle[aria-expanded="true"] svg{transform:rotate(90deg)}
.library-disclosure{display:grid;grid-template-rows:0fr;opacity:0;visibility:hidden;transition:grid-template-rows 180ms ease,opacity 140ms ease,visibility 0s 180ms}
.library-disclosure.expanded{grid-template-rows:1fr;opacity:1;visibility:visible;transition:grid-template-rows 180ms ease,opacity 140ms ease,visibility 0s}
.library-disclosure-inner{min-height:0;overflow:hidden}
.library-controls{margin-top:0}
.library-card{padding:25px 26px;min-height:0;gap:15px;border-color:#e4e8ef;border-radius:10px;transition:border-color 150ms ease,background-color 150ms ease}
.library-card:hover{transform:none;border-color:#a8bce1;background:#fcfdff}
.library-card-title{display:flex;align-items:baseline;justify-content:space-between;gap:18px}
.library-card-title :is(h2,h3){font-family:'DM Sans',system-ui,sans-serif;font-size:1.1875rem;line-height:1.4;font-weight:600;letter-spacing:normal;margin:0}
.library-card-title>svg{width:16px;height:16px;flex:none;align-self:center;color:#71839d}
.library-card p{font-size:1rem;line-height:1.65;margin:0}
.card-milestone{margin-top:auto;padding-top:4px;color:var(--muted);font-size:.875rem;line-height:1.6}
.card-milestone>span{font-weight:500;color:#455a78}
.calendar-top{margin-top:0}
.calendar-stat .blue-number{font-family:inherit;font-size:1rem;font-weight:500;line-height:inherit;color:var(--ink)}
.topic-header h1{font-size:clamp(2.5rem,4vw,3.15rem)}
.topic-topline{font-size:.875rem}
.topic-deck{max-width:780px}
.topic-main .prose{max-width:780px}
.brief-section>h2{margin-bottom:20px}
@media(min-width:801px) and (max-width:1200px){.shell{--sidebar-width:224px}}
@media(max-width:800px){
 .shell,.shell.sidebar-collapsed{display:block}
 .sidebar,.shell.sidebar-collapsed .sidebar{display:flex;position:fixed;z-index:50;top:0;left:0;width:min(320px,calc(100vw - 44px));height:100vh;height:100dvh;padding:26px 20px;opacity:0;visibility:hidden;transform:translateX(-100%);transition:transform 180ms ease,opacity 140ms ease,visibility 0s 180ms}
 .sidebar.open,.shell.sidebar-collapsed .sidebar.open{opacity:1;visibility:visible;transform:translateX(0);transition:transform 180ms ease,opacity 140ms ease,visibility 0s}
 .navigation-close{display:grid;place-items:center;width:36px;height:40px;padding:8px;background:none;border:0;border-radius:6px;flex:none;color:var(--muted)}
 .navigation-close svg{width:20px;height:20px}
 .navigation-backdrop:not([hidden]){display:block;position:fixed;inset:0;z-index:40;background:#18263c40;border:0;padding:0;cursor:default}
 body.navigation-open{overflow:hidden}

 .menu-toggle{font-size:.875rem}
 .search-box{width:min(340px,100%);min-width:0}
 .main{padding-top:20px}
 .sidebar-foot{margin-top:auto}
 .library-card{padding:23px}
}
@media(max-width:580px){

 .search-box{padding:10px;gap:7px}
 .search-box input{font-size:.875rem;min-width:0}
 .page-heading,.overview-intro{margin-bottom:25px}
 .library-card{padding:23px 22px}
 .library-card-title :is(h2,h3){font-size:1.1875rem}
}
@media(prefers-reduced-motion:reduce){.shell,.sidebar,.shell.sidebar-collapsed .sidebar,.sidebar.open,.shell.sidebar-collapsed .sidebar.open,.library-disclosure,.library-disclosure.expanded,.library-toggle svg,.library-card{transition:none}}
@media print{.shell,.shell.sidebar-collapsed{display:block}.navigation-backdrop{display:none!important}.main{padding:0;max-width:none}}

/* Trial comparisons: stable controls, readable labels, and separate value rows. */
.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip-path:inset(50%);white-space:nowrap;border:0}
.mini-result{margin:18px 0 22px}
.mini-result-heading{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:16px;align-items:baseline;margin-bottom:11px;font-size:.9375rem;line-height:1.5;color:#d0ddf7}
.mini-result-heading strong{font-size:1.125rem;font-weight:500;color:#fff;white-space:nowrap;font-variant-numeric:tabular-nums}
.mini-result-heading small{font-size:.8125rem;color:#bacbea;font-weight:400}
.mini-track i{margin-left:auto}
.mini-caption{font-size:.8125rem;line-height:1.6}
.chart-controls{display:flex;flex-direction:column;align-items:stretch;gap:20px;padding:24px}
.study-selector{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px;width:100%}
.study-button{padding:16px 18px;gap:5px;text-align:left;min-width:0;border:1px solid #dce4f1;background:transparent}
.study-button strong{font-size:1rem;letter-spacing:normal;line-height:1.5;color:#485d7c}
.study-button span{font-size:.875rem;line-height:1.5}
.study-button .study-regimen{color:#526b8b}
.study-button.selected{border-color:#8faee5;box-shadow:none}
.study-button.selected strong{color:var(--blue)}
.metric-controls{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:4px;max-width:420px;width:100%;align-self:flex-start;padding:4px}
.metric-button{padding:10px 12px;white-space:normal;font-size:.875rem;line-height:1.4}
.chart-heading{align-items:flex-start;margin-bottom:24px;flex-wrap:wrap}
.chart-heading h3{font-size:1.25rem;line-height:1.4;margin-bottom:6px}
.chart-heading p{font-size:.875rem;line-height:1.6}
.chart-viewport{overflow:visible;max-width:100%;margin:0}
.result-plot{padding:0 3px}
.result-row{--series:#164ec9;--series-soft:#dce7fb;margin-bottom:17px}
.result-row.comparator{--series:#647896;--series-soft:#e5eaf1}
.result-row-heading{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:18px;align-items:baseline;margin-bottom:6px;color:#31425c;font-size:1rem;line-height:1.5}
.result-value{font-size:1.375rem;color:var(--series);font-weight:600;white-space:nowrap;line-height:1.4;font-variant-numeric:tabular-nums}
.result-value small{font-size:.875rem;font-weight:400;color:var(--muted)}
.plot-track{position:relative;height:44px}
.plot-gridline{position:absolute;top:0;height:100%;border-left:1px dashed #e1e6ee}
.plot-gridline.zero{border-left:1px solid #b8c4d6}
.plot-bar{position:absolute;top:16px;height:12px;background:var(--series-soft);border-radius:2px}
.plot-whisker{position:absolute;top:21px;height:2px;background:var(--series)}
.plot-whisker::before,.plot-whisker::after{content:'';position:absolute;top:-5px;height:12px;width:2px;background:var(--series)}
.plot-whisker::before{left:-1px}.plot-whisker::after{right:-1px}
.plot-point{position:absolute;top:16px;margin-left:-6px;width:12px;height:12px;background:var(--series);border:2px solid white;border-radius:50%}
.plot-axis{position:relative;height:24px;margin-top:-4px;color:var(--muted);font-size:.875rem;font-variant-numeric:tabular-nums}
.plot-axis>span{position:absolute;top:0;transform:translateX(-50%)}
.plot-axis>span:first-child{transform:none}.plot-axis>span:last-child{transform:translateX(-100%)}
.plot-axis-label{color:var(--muted);font-size:.875rem;line-height:1.5;text-align:center;margin-top:9px}
.chart-annotation{display:flex;flex-wrap:nowrap;align-items:baseline;gap:10px;font-size:.875rem;line-height:1.65;margin:22px 0}
.annotation-key{flex:none}
.chart-data summary{font-size:.875rem;line-height:1.5}
.study-context{display:block}
.study-context h3{font-family:'DM Sans',system-ui,sans-serif;font-size:1.125rem;font-weight:600;line-height:1.5;margin:0 0 22px;color:#334d73}
.study-context dl{display:grid;grid-template-columns:1fr;gap:18px;columns:auto;font-size:.9375rem;line-height:1.7;margin:0 0 22px}
.study-context dt{font-size:.875rem;margin:0 0 5px;font-weight:600}
.study-context dd{margin:0}
.study-context .text-link{font-size:.875rem;line-height:1.6}
.timeline-tab{min-width:0;text-align:left}
.timeline-tab[aria-pressed="true"]{color:var(--blue)}
.journey-controls{flex-wrap:wrap}
.journey-controls>span{display:block}
.timeline-current{padding:17px 0 12px;margin:0;font-size:.9375rem;line-height:1.7;color:#435d83}
.timeline-current strong{display:block;margin-bottom:5px;font-size:.875rem;font-weight:600}
.rail-milestones strong{display:block;font-size:.9375rem;font-weight:500;line-height:1.5;color:#3e5578;margin-bottom:6px}
.rail-milestones span{font-size:.875rem;line-height:1.5}
.select-wrap>span{font-size:.875rem}
@media(max-width:1250px) and (min-width:801px){.study-context dl{grid-template-columns:repeat(3,minmax(0,1fr));gap:24px}.study-context h3{max-width:none}}
@media(max-width:580px){
 .chart-controls{padding:18px;gap:16px}
 .study-button{padding:12px;gap:4px}
 .study-button strong{font-size:.9375rem}
 .study-button .study-regimen{font-size:.875rem}
 .metric-button{padding:10px 6px}
 .chart-main{padding:23px 19px}
 .result-row-heading{gap:12px;font-size:.9375rem}
 .result-value{font-size:1.25rem}
 .plot-axis-label{font-size:.8125rem;text-align:left}
 .study-context{padding:23px 20px}
 .journey-controls{gap:12px}
 .journey-controls>span{order:-1;flex-basis:100%;text-align:center;font-size:.875rem}
 .mini-result-heading{font-size:.875rem;gap:10px}
}
@media(max-width:380px){.study-selector{grid-template-columns:1fr}.study-button{padding:12px 14px}}

.result-plot{animation:plotReveal 150ms ease-out}@keyframes plotReveal{from{opacity:0}to{opacity:1}}@media(prefers-reduced-motion:reduce){.result-plot{animation:none}}

/* Timeline stops identify events first; dates and future status provide context. */
.journey-line{position:relative;grid-template-columns:repeat(6,minmax(145px,1fr));overflow-x:auto;overscroll-behavior-inline:contain}
.journey-label{display:block;font-size:.9375rem;font-weight:500;line-height:1.45;color:#3b5274;margin-top:17px;min-height:4.35em;overflow-wrap:break-word}
.journey-date{margin-top:8px;color:var(--muted);font-size:.8125rem;line-height:1.5}
.journey-stop.active .journey-label{color:var(--blue);font-weight:600}
.journey-stop.active .journey-date{color:var(--muted)}
.journey-stop small{margin-top:6px;font-size:.75rem;line-height:1.5}
@media(max-width:800px){.journey-stop{min-width:160px}.journey-label{font-size:.9375rem}}

/* Each explainer has one reading surface; the index is only a way to choose it. */
.explainer-index{display:grid;max-width:980px;background:#fff;border:1px solid var(--line);border-radius:12px;overflow:hidden}
.explainer-entry{display:grid;grid-template-columns:minmax(0,1fr) 20px;align-items:center;gap:25px;padding:28px 30px;border-bottom:1px solid var(--line);transition:background-color 150ms ease}
.explainer-entry:last-child{border-bottom:0}
.explainer-entry:hover{background:#f8faff}
.explainer-entry:focus-visible{outline-offset:-4px}
.explainer-entry h2{font-family:'DM Sans',system-ui,sans-serif;font-size:1.25rem;font-weight:600;line-height:1.4;margin:0 0 8px}
.explainer-entry p{font-size:1rem;line-height:1.65;color:var(--muted);max-width:740px;margin:0}
.explainer-entry>svg{width:20px;color:var(--blue)}
.explainer-back{margin-bottom:23px;font-size:.875rem}
.explainer-back svg{transform:rotate(180deg)}
.explainer-content{min-width:0}
.explainer-content>.section-copy{margin-bottom:24px}
.explainer-content .chart-workspace{margin-top:0}
@media(max-width:580px){.explainer-entry{padding:23px;gap:16px}.explainer-entry h2{font-size:1.125rem}.explainer-back{margin-bottom:20px}}
@media(prefers-reduced-motion:reduce){.explainer-entry{transition:none}}

/* Sidebar links scroll independently of the always-reachable controls. */

.menu-toggle{display:grid;place-items:center;width:36px;height:36px;padding:8px;margin-left:-8px;border-radius:8px}
.menu-toggle svg{width:20px;height:20px}
.search-box{padding:7px 11px}
.main{padding-top:16px}
.sidebar{overflow:hidden}
.sidebar>nav{flex:1 1 auto;min-height:0;overflow-y:auto;overscroll-behavior:contain;scroll-padding-block:8px}
.sidebar-heading,.sidebar-foot{flex-shrink:0}
.sidebar>nav .library-toggle:focus-visible{outline-offset:-3px}
.sidebar>nav a:focus-visible{outline-offset:-3px}
@media(max-width:800px){
 .menu-toggle{width:44px;height:44px;margin-left:-8px}
 .search-box{padding:9px 11px}
 .sidebar,.shell.sidebar-collapsed .sidebar{padding-top:max(20px,env(safe-area-inset-top,0px));padding-bottom:max(16px,env(safe-area-inset-bottom,0px));gap:20px}
 .navigation-close{width:44px;height:44px}
}
@media print{html{scroll-padding-top:0}.main{padding:0}}

/* Compact agenda dates above each event keep the title at the full card width. */
.dynamic-event{grid-template-columns:minmax(0,1fr);gap:6px}
.event-date-text{font-size:.875rem;line-height:1.4;font-weight:600;font-variant-numeric:tabular-nums}
.dynamic-event h3{margin:0 0 6px}

/* A floating sidebar control replaces the full-width utility bar. */
.shell{--navigation-edge:var(--sidebar-width)}
.shell.sidebar-collapsed{--navigation-edge:0px}
.menu-toggle{position:fixed;top:max(18px,env(safe-area-inset-top,0px));left:calc(var(--navigation-edge) + 10px);z-index:30;width:36px;height:36px;margin:0;padding:8px;border:1px solid var(--line);border-radius:9px;background:var(--surface);box-shadow:0 2px 8px #18263c08;transition:left 180ms ease,background-color 140ms ease}
.main{padding-top:32px;padding-left:58px}
.sidebar-search{width:100%;min-width:0;flex-shrink:0;padding:8px 10px;background:var(--paper)}
.sidebar-search input{font-size:1rem;min-width:0}
html{scroll-padding-top:16px}
@media(max-width:800px){
 .shell{--navigation-edge:0px}
 .menu-toggle{width:44px;height:44px;top:max(10px,env(safe-area-inset-top,0px));left:max(10px,env(safe-area-inset-left,0px))}
 .main{padding-top:calc(68px + env(safe-area-inset-top,0px));padding-left:20px}
 .sidebar-search kbd{display:none}
 html{scroll-padding-top:68px}
}
@media(max-width:580px){.main{padding-left:17px}}
@media(prefers-reduced-motion:reduce){.menu-toggle{transition:none}}
@media print{.menu-toggle{display:none!important}.main{padding:0}html{scroll-padding-top:0}}

/* Program timelines are individual reading pages with a quiet browsing index. */
.timeline-index-topic{display:block;color:var(--muted);font-size:.875rem;margin-bottom:7px;line-height:1.5}
.timeline-page-links{display:flex;justify-content:space-between;align-items:center;flex-wrap:wrap;gap:15px;margin-bottom:24px}
.timeline-page-links .explainer-back{margin:0}
.timeline-intro{padding-top:17px}
.timeline-current{padding-top:0}
.journey-line{grid-template-columns:repeat(var(--timeline-step-count,6),minmax(145px,1fr))}
.journey-copy h2{font-family:'Instrument Serif',Georgia,serif;font-size:2.1rem;font-weight:400;line-height:1.2;margin:16px 0}
.topic-timelines{margin:28px 0;padding:24px 0;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.topic-timelines>h2{font-size:1.125rem;margin-bottom:18px}
.topic-timeline-link{display:grid;grid-template-columns:minmax(0,1fr) 18px;align-items:center;gap:20px;padding:12px 0}
.topic-timeline-link h3{font-size:1.0625rem;font-weight:600;margin:0 0 6px;color:var(--blue)}
.topic-timeline-link p{font-size:.9375rem;color:var(--muted);margin:0}
.topic-timeline-link>svg{width:18px;color:var(--blue)}
.topic-timeline-link:hover h3{text-decoration:underline}
@media(max-width:580px){.journey-copy h2{font-size:1.8rem}.timeline-page-links{align-items:flex-start;flex-direction:column}.timeline-page-links .text-link{line-height:1.5}}

.journey-stop.future.active .journey-dot{background:var(--surface);color:var(--blue);border:2px solid var(--blue)}

/* Trial safety stays beside efficacy, with one stable treatment order. */
.result-view-controls{display:flex;gap:24px;border-bottom:1px solid var(--line);margin-bottom:-25px}
.result-view-button{background:none;border:0;border-bottom:2px solid transparent;border-radius:0;padding:12px 0 15px;color:var(--muted);font-size:.9375rem;line-height:1.4;text-align:left}
.result-view-button.selected{color:var(--blue);border-bottom-color:var(--blue);font-weight:600}
.result-view-button:hover{color:var(--blue)}
.result-view-button:focus-visible{outline:2px solid var(--blue);outline-offset:4px;border-radius:3px}
.chart-main>.metric-controls{margin:0 0 26px}
.safety-bridge{border-top:1px solid var(--line);padding-top:18px;margin-top:18px;font-size:.875rem;line-height:1.7;color:var(--muted)}
.safety-bridge p{margin:0 0 10px}.safety-bridge strong{font-weight:600;color:var(--ink)}
.safety-bridge button{display:inline-flex;align-items:center;gap:8px;text-align:left}.safety-bridge svg{width:16px;height:16px;flex:none}
.safety-panel{padding:30px 28px}
.safety-heading{display:flex;justify-content:space-between;align-items:baseline;gap:10px 20px;flex-wrap:wrap;margin-bottom:15px}
.safety-heading h3,.safety-common h3{font-size:1.25rem;margin:0;font-weight:600}
.safety-heading>span{font-size:.8125rem;color:var(--muted)}
.safety-summary{font-size:1.0625rem;line-height:1.75;color:var(--ink);max-width:790px;margin:0 0 10px}
.safety-window{font-size:.875rem;line-height:1.7;color:var(--muted);max-width:790px;margin:0 0 22px}
.safety-table-wrap{border:0;border-radius:0;margin:0}
.safety-table{table-layout:fixed;line-height:1.5}
.safety-table caption{text-align:left;font-size:.8125rem;color:var(--muted);padding:0 0 10px}
.safety-table th:first-child{width:40%}
.safety-table thead th{font-size:.8125rem;vertical-align:top;background:#f6f8fc;color:#364d70;padding:15px 16px;font-weight:600}
.safety-table tbody th{font-size:.875rem;font-weight:500;color:var(--ink);background:none}
.safety-table tbody th,.safety-table td{padding:15px 16px;border-bottom:1px solid var(--line);vertical-align:middle}
.safety-table tbody tr:last-child th,.safety-table tbody tr:last-child td{border-bottom:1px solid var(--line)}
.safety-denominator,.safety-count,.safety-table th small{display:block;font-size:.75rem;font-weight:400;color:var(--muted);margin-top:4px;line-height:1.5}
.safety-table td{font-variant-numeric:tabular-nums}.safety-table td strong{font-size:1.125rem;font-weight:550;white-space:nowrap;color:var(--ink)}
.safety-missing{font-size:.8125rem;color:var(--muted)}
.safety-common{margin-top:34px}.safety-common>p{font-size:.875rem;line-height:1.7;color:var(--muted);margin:9px 0 20px}
.safety-notes{margin-top:28px;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px 30px}
.safety-notes article{padding-top:16px;border-top:1px solid var(--line)}
.safety-notes h4{font-size:.9375rem;margin:0 0 8px;font-weight:600}
.safety-notes p{font-size:.875rem;line-height:1.75;color:var(--muted);margin:0}
.safety-methods{margin-top:18px}
@media(max-width:600px){
 .result-view-controls{gap:20px;margin-bottom:-19px}
 .result-view-button{font-size:.875rem}
 .safety-panel{padding:25px 18px}
 .safety-notes{grid-template-columns:1fr;gap:16px}
 .safety-table th:first-child{width:38%}
 .safety-table thead th{padding:12px 8px;font-size:.8125rem;overflow-wrap:break-word}
 .safety-table tbody th,.safety-table td{padding:13px 8px}
 .safety-table tbody th{font-size:.875rem}
 .safety-table td strong{font-size:1rem}
 .safety-denominator,.safety-count,.safety-table th small{font-size:.75rem}
}

/* Anatomical topic marks add recognition without another layer of labels. */
.library-card-title{display:grid;grid-template-columns:36px minmax(0,1fr) 16px;align-items:center;gap:13px}
.library-card-title .topic-icon{display:block;width:36px;height:36px;object-fit:contain;flex:none}
.library-card-title>svg{grid-column:3}
@media(max-width:480px){.library-card-title{grid-template-columns:32px minmax(0,1fr) 16px;gap:11px}.library-card-title .topic-icon{width:32px;height:32px}}
.brand-mark{display:block;object-fit:contain;flex:none}

/* A large, quiet plotting surface; study context appears only when requested. */
.weight-intro{color:var(--muted);font-size:1rem;margin:-4px 0 22px;max-width:760px}
.weight-toolbar{display:flex;justify-content:space-between;gap:18px;align-items:center;border-bottom:1px solid var(--line);padding-bottom:0}
.weight-view-tabs{display:flex;gap:26px}
.weight-view-tabs button{border:0;border-bottom:2px solid transparent;background:none;border-radius:0;padding:15px 0;font-size:1rem;color:var(--muted)}
.weight-view-tabs button[aria-selected=true]{color:var(--blue);border-bottom-color:var(--blue);font-weight:600}
.weight-expand{display:inline-flex;gap:9px;align-items:center;white-space:nowrap;font-size:.875rem;padding:9px 13px}
.weight-filters{display:flex;gap:12px;align-items:flex-end;flex-wrap:wrap;padding:22px 0 12px}
.weight-filters>label{display:flex;flex-direction:column;gap:7px;min-width:140px;flex:1}
.weight-filters label>span{font-size:.8125rem;color:var(--muted)}
.weight-filters select,.weight-search{border:1px solid var(--line);border-radius:8px;background:#fff;min-height:43px;color:var(--ink);font-size:.875rem}
.weight-filters select{padding:9px 26px 9px 11px;max-width:100%}
.weight-filters .weight-search{display:flex;flex-direction:row;align-items:center;gap:9px;padding:9px 12px;flex:1.15;min-width:175px}
.weight-search svg{width:16px;height:16px;color:var(--muted);flex:none}.weight-search input{border:0;background:none;outline:0;min-width:0;width:100%;font-size:.875rem}.weight-search:focus-within{outline:2px solid #729dff;outline-offset:2px}
.weight-meta{display:flex;justify-content:space-between;gap:15px;margin:5px 0 18px;color:var(--muted);font-size:.8125rem}
.weight-hormones{border:0;padding:4px 0 12px;margin:0;min-width:0}.weight-hormones legend{font-size:.875rem;color:var(--muted);padding:0}.weight-hormone-options{display:flex;align-items:center;flex-wrap:wrap;gap:8px;margin:7px 0}.weight-hormone-options label{display:flex;align-items:center;gap:7px;padding:6px 10px;border:1px solid var(--line);border-radius:6px;cursor:pointer;font-size:.875rem;line-height:1.5;background:#fff}.weight-hormone-options label:has(input:checked){border-color:#bdcdee;background:#f0f4fd;color:#244fc5}.weight-hormone-options input{width:15px;height:15px;margin:0;accent-color:#244fc5}.weight-hormones p{font-size:.8125rem;color:var(--muted);margin:5px 0 0}.weight-text-button{border:0;background:none;color:var(--blue);font-size:.875rem;padding:7px 8px;cursor:pointer}.weight-text-button:hover{text-decoration:underline}
.weight-mechanism{padding:0 0 22px}.weight-mechanism h3{font-size:.875rem;font-weight:500;color:var(--muted);margin:0 0 10px}.weight-target-list{display:flex;gap:9px;flex-wrap:wrap}.weight-target{display:flex;align-items:center;gap:9px;flex-wrap:wrap;background:#f0f4fd;border:1px solid #dce5f5;border-radius:7px;padding:8px 12px;color:#244fc5;font-size:.875rem}.weight-target strong{font-weight:600}.weight-target span{color:#4e617f;font-size:.8125rem}.weight-target:hover{border-color:#244fc5}.weight-target-blocks{background:#fff5e8;border-color:#ecdbbf;color:#86530d}.weight-target-blocks span{color:#7a613e}.weight-mechanism p{margin:11px 0 0;font-size:.9375rem;line-height:1.65;color:var(--muted);max-width:900px}
.weight-chart-scroll{overflow:auto;max-width:100%;background:#fff;border:1px solid var(--line);border-radius:12px;overscroll-behavior-x:contain;scrollbar-width:thin}
.weight-svg{display:block;width:100%;min-width:1200px;height:auto;font-family:'DM Sans',sans-serif;font-size:17px}
.weight-grid line{stroke:#e6ebf2;stroke-width:1}.weight-grid .weight-grid-vertical{stroke:#f1f3f7}.weight-grid text{fill:#748198;font-size:17px}.weight-grid .weight-axis-title{font-size:18px;fill:#44536c;font-weight:500}
.weight-point,.weight-curve{cursor:pointer;outline:none}.weight-leader{stroke:#b8c4d8;stroke-width:1.2}.weight-label-bg{fill:white;fill-opacity:.93}.weight-map-label{fill:#43516a;font-size:17px;font-weight:500}
.weight-marker{stroke:white;stroke-width:2;fill:var(--point-color)}.weight-hit{fill:transparent;stroke:none}
.weight-point:hover .weight-map-label,.weight-point:focus .weight-map-label,.weight-point.is-selected .weight-map-label{fill:var(--point-color);font-weight:700}
.weight-point:hover .weight-label-bg,.weight-point:focus .weight-label-bg,.weight-point.is-selected .weight-label-bg{fill:#edf3ff;stroke:var(--point-color);stroke-width:1}
.weight-point.is-selected .weight-marker,.weight-point:focus .weight-marker{stroke:var(--point-color);stroke-width:3;paint-order:stroke;fill:white}
.weight-curve-line{fill:none;stroke:var(--point-color);stroke-width:3;stroke-linejoin:round;stroke-linecap:round}.weight-curve-hit{fill:none;stroke:transparent;stroke-width:22}.weight-curve-dot{fill:var(--point-color);stroke:white;stroke-width:1.2}.weight-curve-dot.approximate{fill:white;stroke:var(--point-color);stroke-width:1.5}
.weight-curve:hover .weight-curve-line,.weight-curve:focus .weight-curve-line,.weight-curve.is-selected .weight-curve-line{stroke-width:5}
.weight-svg:has(.weight-curve.is-selected) .weight-curve:not(.is-selected){opacity:.22}.weight-svg:has(.weight-curve.is-selected) .weight-curve:hover,.weight-svg:has(.weight-curve.is-selected) .weight-curve:focus{opacity:1}
.weight-legend{display:flex;align-items:center;gap:14px 24px;flex-wrap:wrap;margin:0 0 15px;font-size:.875rem;color:var(--muted)}
.weight-legend>span{display:inline-flex;gap:8px;align-items:center}.weight-legend i{width:9px;height:9px;display:block;border-radius:50%}.weight-square-key i{border-radius:1px;background:#68778c}.weight-legend .weight-legend-help{margin-left:auto;font-size:.8125rem}
.weight-curve-legend{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px 18px;margin:22px 0 14px}
.weight-curve-legend label{display:flex;gap:9px;align-items:flex-start;cursor:pointer;font-size:.875rem;line-height:1.4;color:var(--ink)}
.weight-curve-legend input{accent-color:var(--point-color);margin:3px 0 0;width:16px;height:16px;flex:none}.weight-line-key{width:18px;height:3px;background:var(--point-color);margin-top:9px;flex:none}.weight-curve-legend small{display:block;color:var(--muted);font-size:.75rem;line-height:1.5;margin-top:3px}
.weight-chart-note{color:var(--muted);font-size:.875rem;margin:13px 0 25px;line-height:1.65;max-width:940px}
.weight-detail-empty{display:flex;align-items:center;gap:12px;padding:21px 0;color:var(--muted);border-top:1px solid var(--line);border-bottom:1px solid var(--line)}.weight-detail-empty svg{width:20px;height:20px}.weight-detail-empty p{font-size:.9375rem;margin:0}
.weight-detail{padding:26px 0 22px;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.weight-detail-heading{display:flex;justify-content:space-between;gap:20px;margin-bottom:25px}.weight-detail-heading h2{font-size:1.6rem;margin:0 0 7px}.weight-detail-heading p{font-size:1rem;margin:0 0 8px}.weight-detail-heading>div>span{color:var(--muted);font-size:.875rem}
.weight-detail-value{text-align:right;min-width:180px;display:flex;flex-direction:column;gap:5px}.weight-detail-value strong{font-family:'Instrument Serif',Georgia,serif;color:var(--blue);font-size:3.2rem;font-weight:400;line-height:1}.weight-detail-value strong small{font:inherit;font-size:1.5rem;margin-left:3px}.weight-detail-value>small{color:var(--muted);font-size:.8125rem}
.weight-detail-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:28px}.weight-detail-grid h3{font-size:.9375rem;margin:0 0 8px}.weight-detail-grid p{font-size:.875rem;line-height:1.7;color:var(--muted);margin:0}
.weight-study-caveat,.weight-current-status{font-size:.875rem;color:var(--muted);line-height:1.7;margin:20px 0 0}
.weight-source-row{display:flex;gap:9px 22px;flex-wrap:wrap;margin-top:18px}.weight-source-row a,.weight-coverage a{display:inline-flex;align-items:center;gap:6px;color:var(--blue);font-size:.8125rem;line-height:1.6}.weight-source-row svg,.weight-coverage svg{width:15px;height:15px;flex:none}
.weight-methods{margin:22px 0 0;border-bottom:1px solid var(--line);padding:0 0 20px}.weight-methods>summary{font-size:.9375rem;font-weight:500;cursor:pointer;padding:5px 0}.weight-methods[open]>summary{margin-bottom:17px}.weight-methods p{font-size:.9375rem;line-height:1.75;color:var(--muted);max-width:900px}.weight-methods a{color:var(--blue)}.weight-methods table{font-size:.875rem;min-width:900px}.weight-methods th{font-weight:500}.weight-methods td,.weight-methods th{vertical-align:top;line-height:1.65}.weight-methods table small{display:block;min-width:150px;color:var(--muted);font-size:.75rem;line-height:1.5;margin-top:5px}.weight-methods h3{margin-top:25px;font-size:1rem}
.weight-coverage{list-style:none;margin:0;padding:0;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:22px 32px}.weight-coverage li{border-top:1px solid var(--line);padding:15px 0}.weight-coverage strong{font-weight:500;font-size:1rem}.weight-coverage p{font-size:.875rem;margin:6px 0 8px}
.weight-dialog{width:calc(100vw - 36px);max-width:none;height:calc(100dvh - 36px);max-height:none;border:1px solid var(--line);border-radius:15px;padding:0;background:#f8faff;color:var(--ink)}.weight-dialog::backdrop{background:#12243b70;backdrop-filter:blur(5px)}
.weight-dialog-heading{display:flex;justify-content:space-between;align-items:center;gap:20px;padding:18px 28px;border-bottom:1px solid var(--line);position:sticky;top:0;background:#f8faff;z-index:2}.weight-dialog-heading h2{font-size:1.25rem;margin:0}.weight-dialog-heading button{display:inline-flex;gap:8px;align-items:center;padding:8px 12px}.weight-dialog-heading svg{width:16px;height:16px}
#weight-dialog-body,#a1c-dialog-body{padding:24px 28px 35px}.weight-dialog .weight-svg{min-width:1450px;max-height:none}.weight-dialog .weight-detail{background:transparent;margin-top:22px}.weight-dialog .weight-chart-scroll{background:white}
@media(min-width:1700px){.weight-dialog .weight-svg{min-width:0}}
@media(max-width:850px){.weight-curve-legend{grid-template-columns:repeat(2,minmax(0,1fr))}.weight-detail-grid{grid-template-columns:1fr;gap:18px}.weight-legend .weight-legend-help{margin-left:0}.weight-filters>label{flex-basis:40%}.weight-filters .weight-search{flex-basis:40%}}
@media(max-width:580px){.weight-toolbar{flex-wrap:wrap;gap:10px}.weight-view-tabs{gap:20px;order:2;flex-basis:100%}.weight-expand{margin-left:auto}.weight-meta{font-size:.75rem;flex-wrap:wrap;gap:5px}.weight-curve-legend{grid-template-columns:1fr}.weight-detail-heading{flex-direction:column}.weight-detail-value{text-align:left;align-items:flex-start}.weight-coverage{grid-template-columns:1fr}.weight-dialog{width:calc(100vw - 12px);height:calc(100dvh - 12px)}.weight-dialog-heading{padding:15px}#weight-dialog-body,#a1c-dialog-body{padding:20px 15px}.weight-intro{font-size:.9375rem}}
@media(prefers-reduced-motion:reduce){.weight-point,.weight-curve{transition:none}}
@media print{.weight-toolbar,.weight-filters,.weight-dialog{display:none}.weight-chart-scroll{overflow:visible;border:0}.weight-svg{min-width:0}.weight-detail{break-inside:avoid}}

.weight-precision-key{font-size:.8125rem;color:var(--muted);margin:-5px 0 15px;line-height:1.65}
.weight-policy-endpoint{padding:14px 17px;border-left:2px solid #9fb5dc;background:#f0f5fc;font-size:.875rem;line-height:1.7;margin:22px 0 0;color:#526782}
.weight-shape-key{width:18px;height:18px;flex:none;--point-color:#536780}
.weight-shape-key .weight-marker{stroke-width:0}
.weight-legend-divider{width:1px;height:18px;background:var(--line)}
.weight-legend>span>i{height:4px;width:17px;border-radius:2px}
.weight-identity{display:grid;grid-template-columns:1.15fr 1fr;gap:24px 36px;border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:20px 0;margin:0 0 24px}
.weight-identity h3{font-size:.8125rem;font-weight:500;color:var(--muted);margin:0 0 11px}
.weight-brand,.weight-company{display:flex;flex-direction:column;gap:4px;margin-bottom:12px}.weight-brand:last-child,.weight-company:last-child{margin-bottom:0}
.weight-brand>a,.weight-company>a{color:var(--blue);font-size:1rem;font-weight:500;width:fit-content}.weight-identity a:hover{text-decoration:underline}
.weight-brand>span,.weight-company>span{color:var(--muted);font-size:.875rem;line-height:1.65}
.weight-other-brands{margin-top:14px}.weight-other-label{display:block;font-size:.75rem;color:var(--muted);margin-bottom:6px}.weight-other-brands .weight-brand{flex-direction:row;align-items:baseline;gap:9px;flex-wrap:wrap;margin-bottom:5px}.weight-other-brands .weight-brand>a{font-size:.875rem;color:#516682;font-weight:500}.weight-other-brands .weight-brand>span{font-size:.8125rem}
.weight-brand-note{font-size:.875rem;line-height:1.7;color:var(--muted);margin:0}
.weight-history{margin-top:24px;border-top:1px solid var(--line);padding-top:6px}.weight-history>summary{list-style:none;display:flex;align-items:center;gap:10px;padding:15px 0;font-size:1rem;font-weight:500;cursor:pointer}.weight-history>summary::-webkit-details-marker{display:none}.weight-history>summary::marker{content:''}.weight-history-count{font-size:.8125rem;font-weight:400;color:var(--muted);margin-left:auto}.weight-history>summary>svg{width:16px;height:16px;color:var(--muted);transition:transform .16s ease}.weight-history[open]>summary>svg{transform:rotate(90deg)}
.weight-history-content{padding:4px 0 8px}.weight-history-context{font-size:.875rem;color:var(--muted);margin:0 0 8px}.weight-history-coverage{font-size:1rem;color:var(--muted);line-height:1.7;margin:0 0 25px;max-width:960px}.weight-history-date>span{display:block;font-size:.875rem;color:var(--muted);margin-top:3px}.weight-history ol{list-style:none;padding:0;margin:0;max-width:960px}.weight-history li{display:grid;grid-template-columns:118px minmax(0,1fr);gap:28px;position:relative;padding:0 0 29px}.weight-history li:before{content:'';position:absolute;left:132px;top:8px;bottom:-8px;border-left:1px solid #c7d4e8}.weight-history li:after{content:'';position:absolute;left:128px;top:7px;width:9px;height:9px;border-radius:50%;border:2px solid #6686bb;background:#f8faff}.weight-history li:last-child{padding-bottom:0}.weight-history li:last-child:before{display:none}.weight-history li:last-child:after{background:var(--blue);border-color:var(--blue)}
.weight-history time{font-size:.875rem;color:#657994;line-height:1.65;white-space:nowrap}.weight-history li h3{font-size:1.0625rem;font-weight:500;margin:0 0 6px;line-height:1.5}.weight-history li p{font-size:1rem;color:var(--muted);line-height:1.7;margin:0 0 8px}.weight-history li a{display:inline-flex;align-items:center;gap:6px;font-size:.8125rem;color:var(--blue);line-height:1.5}.weight-history li a svg{width:14px;height:14px}.weight-history-checked{font-size:.75rem;color:var(--muted);margin:24px 0 0}
@media(max-width:650px){.weight-identity{grid-template-columns:1fr;gap:22px}.weight-history li{grid-template-columns:1fr;gap:5px;padding:0 0 26px 25px}.weight-history li:before{left:5px}.weight-history li:after{left:1px}.weight-history time{font-size:.8125rem}.weight-history li p{font-size:.9375rem}.weight-legend-divider{display:none}}
@media(prefers-reduced-motion:reduce){.weight-history>summary>svg{transition:none}}

.weight-region-sources{font-size:.75rem}.weight-region-sources a{color:#516682;text-decoration:underline;text-decoration-color:#b9c7dc;text-underline-offset:2px}

.weight-brand-caveat{font-size:.8125rem;margin:13px 0 0}

/* Outcome explorers share controls, while keeping units and populations explicit. */
.outcome-links{display:flex;align-items:center;gap:22px;margin:-8px 0 24px;font-size:.9375rem}.outcome-links a{color:var(--muted);text-decoration:none}.outcome-links a:hover{color:var(--blue)}.outcome-links [aria-current]{color:var(--blue);font-weight:650;border-bottom:2px solid currentColor;padding-bottom:5px}.a1c-comparator{display:flex;align-items:baseline;flex-wrap:wrap;gap:8px 18px;padding:14px 0 18px;margin-bottom:22px;border-bottom:1px solid var(--line);font-size:.9375rem}.a1c-comparator strong{font-weight:600}.a1c-comparator small{color:var(--muted)}.a1c-detail-grid{margin-bottom:25px}

/* Lipid therapy charts: aligned evidence rows and a separate clinical-outcomes workspace. */
.explainer-group{margin:0}
.explainer-group+.explainer-group{border-top:1px solid var(--line)}
.explainer-group>h2{font-size:1rem;color:var(--muted);margin:0;padding:24px 30px 0}
@media(max-width:580px){.explainer-group>h2{padding:23px 23px 0}}
.lipid-page-links{display:flex;gap:24px;flex-wrap:wrap;margin:-8px 0 27px;font-size:1rem;color:var(--muted)}.lipid-page-links [aria-current]{color:var(--blue);font-weight:600}.lipid-page-links a:hover{color:var(--blue)}
.lipid-metric-buttons{display:flex;flex-wrap:wrap;gap:8px;margin:0 0 18px}.lipid-metric-buttons button{background:#fff;border:1px solid var(--line);border-radius:7px;padding:9px 15px;color:var(--muted);font-size:.9375rem}.lipid-metric-buttons button[aria-pressed=true]{background:var(--soft);color:var(--blue);border-color:#aec3ed;font-weight:600}
.lipid-toolbar{display:flex;justify-content:space-between;align-items:center;gap:18px;border-bottom:1px solid var(--line)}.lipid-view-tabs{display:flex;gap:25px}.lipid-view-tabs button{border:0;border-bottom:2px solid transparent;background:none;padding:14px 0;color:var(--muted);font-size:.9375rem}.lipid-view-tabs button[aria-selected=true]{color:var(--blue);border-bottom-color:var(--blue);font-weight:600}
.lipid-filters{display:flex;align-items:flex-end;gap:12px;flex-wrap:wrap;margin:20px 0 16px}.lipid-filters label{display:flex;flex-direction:column;gap:6px;flex:1;min-width:165px}.lipid-filters label>span{font-size:.875rem;color:var(--muted)}.lipid-filters select{max-width:100%;width:100%;background:#fff;border:1px solid var(--line);border-radius:7px;padding:10px 27px 10px 11px;font-size:.875rem;min-height:43px;color:var(--ink)}.lipid-filters .lipid-search{display:flex;flex-direction:row;align-items:center;gap:10px;background:#fff;border:1px solid var(--line);border-radius:7px;min-height:43px;padding:10px 12px;min-width:190px;flex:1.2}.lipid-search svg{width:17px;height:17px;flex:none;color:var(--muted)}.lipid-search input{border:0;outline:0;min-width:0;width:100%;background:none;font-size:.875rem}.lipid-search:focus-within{outline:2px solid #729dff;outline-offset:2px}
.lipid-meta{display:flex;justify-content:space-between;flex-wrap:wrap;gap:10px;color:var(--muted);font-size:.875rem;margin-bottom:12px}.lipid-context{font-size:.9375rem;color:var(--muted);margin-bottom:20px;max-width:950px}.lipid-chart-scroll{overflow:auto;background:#fff;border:1px solid var(--line);border-radius:12px;scrollbar-width:thin;overscroll-behavior-x:contain}.lipid-svg{display:block;width:100%;min-width:1050px;height:auto;font-family:'DM Sans',sans-serif}.lipid-axis line{stroke:#edf0f5;stroke-width:1}.lipid-axis .lipid-null{stroke:#8b99ad;stroke-dasharray:4 5;stroke-width:1.5}.lipid-axis text{fill:#66758a;font-size:17px}.lipid-therapy{fill:var(--ink);font-weight:600;font-size:19px}.lipid-row-subtitle{fill:#718097;font-size:16px}.lipid-result{fill:var(--ink);font-size:19px;font-weight:500}.lipid-row,.lipid-scatter,.lipid-curve{cursor:pointer;outline:none}.lipid-row-hit{fill:transparent}.lipid-row:hover .lipid-row-hit,.lipid-row:focus .lipid-row-hit,.lipid-row.is-selected .lipid-row-hit{fill:#f1f5fc}.lipid-row:focus .lipid-row-hit,.lipid-row.is-selected .lipid-row-hit{stroke:#8aa9e3;stroke-width:1}.lipid-ci{stroke:var(--lipid-color);stroke-width:2.5;fill:none;stroke-linecap:round}.lipid-stem{stroke:var(--lipid-color);stroke-opacity:.22;stroke-width:7;stroke-linecap:round}.lipid-estimate{fill:var(--lipid-color);stroke:white;stroke-width:1.5}.lipid-estimate.approximate{fill:white;stroke:var(--lipid-color);stroke-width:2}.lipid-hit{fill:transparent}.lipid-leader{stroke:#b8c4d8;stroke-width:1.2}.lipid-label-bg{fill:#fff;fill-opacity:.96}.lipid-map-label{font-size:17px;fill:#3b4d65}.lipid-scatter:hover .lipid-map-label,.lipid-scatter:focus .lipid-map-label,.lipid-scatter.is-selected .lipid-map-label{fill:var(--lipid-color);font-weight:650}.lipid-scatter:focus .lipid-label-bg,.lipid-scatter.is-selected .lipid-label-bg{fill:#edf3ff;stroke:var(--lipid-color)}
.lipid-curve-line{fill:none;stroke:var(--lipid-color);stroke-width:3;stroke-linecap:round;stroke-linejoin:round}.lipid-curve-hit{fill:none;stroke:transparent;stroke-width:22}.lipid-curve:hover .lipid-curve-line,.lipid-curve:focus .lipid-curve-line,.lipid-curve.is-selected .lipid-curve-line{stroke-width:5}.lipid-svg:has(.lipid-curve.is-selected) .lipid-curve:not(.is-selected){opacity:.28}.lipid-class-legend{display:flex;flex-wrap:wrap;gap:12px 22px;margin:16px 0}.lipid-class-legend span{display:flex;align-items:center;gap:8px;font-size:.875rem;color:var(--muted)}.lipid-class-legend i{width:9px;height:9px;border-radius:3px}.lipid-curve-legend{display:grid;grid-template-columns:repeat(auto-fit,minmax(250px,1fr));gap:12px;margin:18px 0}.lipid-curve-legend label{display:flex;align-items:center;gap:9px;font-size:.9375rem;cursor:pointer}.lipid-curve-legend input{accent-color:var(--lipid-color)}.lipid-curve-legend i{height:3px;width:25px;background:var(--lipid-color)}.lipid-curve-legend small{display:block;color:var(--muted);font-size:.8125rem;line-height:1.6}.lipid-plot-note,.lipid-select-hint{font-size:.9375rem;color:var(--muted);max-width:980px;margin:14px 0 24px}.lipid-select-hint{padding:24px 0;border-top:1px solid var(--line)}
.lipid-detail{margin-top:28px;padding-top:28px;border-top:1px solid var(--line)}.lipid-detail-heading{display:flex;justify-content:space-between;gap:30px;margin-bottom:25px}.lipid-detail-heading h2{font-size:1.7rem;margin-bottom:8px}.lipid-detail-heading p{margin:0 0 7px}.lipid-detail-heading span{font-size:.9375rem;color:var(--muted)}.lipid-detail-value{display:flex;flex-direction:column;align-items:flex-end;gap:6px;flex:none}.lipid-detail-value strong{font-size:2.5rem;font-weight:500;color:var(--blue);line-height:1.1}.lipid-detail-value small{font-size:.875rem;color:var(--muted)}.lipid-detail-grid{display:grid;grid-template-columns:1fr 1fr;gap:23px 38px}.lipid-detail-grid h3{font-size:.875rem;color:var(--muted);margin-bottom:8px}.lipid-detail-grid p{font-size:1rem;margin:0}.lipid-identity{color:var(--muted);font-size:.9375rem;margin-top:24px}.lipid-caveat{color:var(--muted);font-size:.9375rem;max-width:980px}.lipid-absolute{display:flex;flex-wrap:wrap;gap:18px 48px;padding:18px 24px;background:#edf3fc;border-radius:10px;margin-bottom:28px}.lipid-absolute>div{display:flex;gap:18px;align-items:baseline}.lipid-absolute span{font-size:.9375rem;color:#4c6283}.lipid-absolute strong{font-size:1.5rem;font-weight:500}.lipid-absolute p{flex-basis:100%;font-size:.875rem;margin:0;color:var(--muted)}.lipid-methods,.lipid-other-markers{border-top:1px solid var(--line);padding:18px 0;margin-top:16px}.lipid-methods summary,.lipid-other-markers summary{font-size:.9375rem;cursor:pointer;color:var(--muted)}.lipid-methods p{font-size:.9375rem;max-width:980px;margin:14px 0}.lipid-methods ul{padding-left:22px}.lipid-methods li{margin:24px 0}.lipid-methods a{color:var(--blue);display:inline-flex;gap:6px;align-items:center;font-size:.9375rem}.lipid-methods a svg{height:14px;width:14px}.lipid-other-markers table{margin-top:18px;width:100%;border-collapse:collapse}.lipid-other-markers td,.lipid-other-markers th{padding:10px 15px;text-align:left;border-bottom:1px solid var(--line);font-size:.9375rem}.lipid-other-markers th{font-weight:500}
#lipid-dialog-body{padding:24px 28px 35px}.weight-dialog .lipid-svg{min-width:1250px}.weight-dialog .lipid-detail{padding:28px 8px 0}
@media(max-width:850px){.lipid-toolbar{align-items:flex-start;flex-wrap:wrap}.lipid-view-tabs{gap:18px}.lipid-toolbar .weight-expand{margin-left:auto}.lipid-detail-grid{grid-template-columns:1fr}.lipid-filters label{flex-basis:calc(50% - 12px)}}
@media(max-width:580px){.lipid-page-links{gap:18px;font-size:.9375rem}.lipid-metric-buttons button{padding:8px 11px;font-size:.875rem}.lipid-view-tabs{overflow-x:auto;max-width:100%;order:2;flex-basis:100%;gap:20px}.lipid-view-tabs button{white-space:nowrap}.lipid-detail-heading{flex-direction:column;gap:17px}.lipid-detail-value{align-items:flex-start}.lipid-absolute{padding:17px;gap:15px}.lipid-absolute>div{justify-content:space-between;width:100%}.lipid-filters label{min-width:140px}#lipid-dialog-body{padding:20px 15px}}

/* Medicine Ahead: compact editorial identity above the working overview. */
.medicine-intro{margin:0 0 28px}.medicine-intro h1{font-size:clamp(2.25rem,4vw,3rem);line-height:1.08;margin:0 0 9px}.medicine-intro p{font-size:1rem;line-height:1.6;color:var(--muted);margin:0;max-width:42rem}.brand{min-width:0}.brand-name>span{white-space:nowrap}
@media(max-width:580px){.medicine-intro{margin-bottom:23px}.medicine-intro p{max-width:25rem}}

.lipid-curve:focus .lipid-estimate,.lipid-curve.is-selected .lipid-estimate{stroke:var(--lipid-color);stroke-width:3}.lipid-curve:focus .lipid-estimate.approximate{stroke-width:3}

/* Atlas sections follow the same catalog order as the sidebar. */
.library-area+.library-area{margin-top:36px;padding-top:28px;border-top:1px solid var(--line)}
.library-area>h2{font-family:'DM Sans',system-ui,sans-serif;font-size:1.125rem;font-weight:500;line-height:1.4;color:var(--muted);margin:0 0 15px;letter-spacing:normal}
@media(max-width:580px){.library-area+.library-area{margin-top:28px;padding-top:22px}.library-area>h2{margin-bottom:12px}}

/* Editorial reading surface */
.editorial-page{max-width:780px;margin:0 auto}.editorial-page h1{font-size:clamp(2.4rem,5vw,4rem);line-height:1.08;margin:14px 0 24px}.editorial-page h1 em{font-family:'Instrument Serif',Georgia,serif;font-weight:400}.editorial-page section{padding:24px 0;border-top:1px solid var(--line)}.editorial-page section h2{font-size:1.35rem;margin:0 0 14px}.editorial-page p,.editorial-page li{font-size:1rem;line-height:1.75}.editorial-page li+li{margin-top:12px}.footer{flex-wrap:wrap;gap:14px}.footer a{color:inherit}

.topic-brief{border:1px solid var(--line);border-top:3px solid var(--blue);background:var(--surface);border-radius:0 0 12px 12px;padding:25px 28px;margin:0 0 32px}.brief-heading{display:flex;align-items:baseline;justify-content:space-between;gap:14px}.brief-heading h2{margin:0;font-size:1.5rem}.brief-heading>span{color:var(--muted);font-size:.875rem}.topic-brief dl{display:grid;grid-template-columns:1fr 1fr;gap:24px 32px;margin:25px 0 16px}.brief-fact:last-child{grid-column:1/-1;border-top:1px solid var(--line);padding-top:20px}.brief-fact dt{font-size:.875rem;color:var(--blue);font-weight:650;margin-bottom:7px}.brief-fact dd{margin:0;font-size:1rem;line-height:1.65}.brief-source{white-space:nowrap;font-size:.875rem;color:var(--blue);text-decoration:underline;text-underline-offset:3px}.brief-source svg{display:inline;width:14px;height:14px;vertical-align:middle}.brief-scope{font-size:.875rem;color:var(--muted);margin:0}.evidence-result{padding:22px 0;border-top:1px solid var(--line);max-width:900px}.evidence-result-meta{display:flex;flex-wrap:wrap;gap:7px;font-size:.875rem;color:var(--muted);line-height:1.5;margin-bottom:8px}.evidence-result h3{margin-bottom:8px}.evidence-result h3 a{color:var(--blue);line-height:1.5}.evidence-result h3 svg{display:inline;width:17px;height:17px;vertical-align:middle}.evidence-result p{margin:0;font-size:1rem}.evidence-result mark{background:#e5edff;color:inherit;font-weight:600}.matching-topics-heading{margin:32px 0 0}.noscript-note{padding:20px;text-align:center;font-size:1rem}.topic-brief,.evidence-result{overflow-wrap:anywhere}@media(max-width:700px){.topic-brief{padding:22px 20px}.brief-heading{display:block}.brief-heading>span{display:block;margin-top:8px}.topic-brief dl{grid-template-columns:1fr;gap:20px}.brief-fact:last-child{grid-column:auto}.evidence-search>.section-heading{align-items:flex-start;flex-direction:column}.editorial-page h1{font-size:2.5rem}}

/* Hormone primer: plain-language physiology beside coordinate-based molecular views. */
.hormone-primer-teaser{display:flex;align-items:center;justify-content:space-between;gap:28px;border:1px solid var(--line);border-left:3px solid var(--blue);background:var(--soft);padding:24px 28px;margin:0 0 32px;border-radius:10px}.hormone-primer-teaser:hover{border-color:#aabfe9}.hormone-primer-teaser h2{margin:9px 0 8px;font-size:1.45rem}.hormone-primer-teaser p{margin:0;max-width:620px;font-size:1rem;color:var(--muted)}.primer-link-label{display:flex;align-items:center;gap:12px;flex:none;font-size:.9375rem;color:var(--blue)}.primer-link-label svg{width:18px;height:18px}.hormone-context-links{font-size:.875rem!important;color:var(--muted)}.hormone-context-links a,.weight-hormones>p>a{color:var(--blue);text-decoration:underline;text-underline-offset:3px}.hormone-primer-page{max-width:1080px;margin:auto}.hormone-primer-header{max-width:770px;margin:32px 0 28px}.hormone-primer-header h1{font-size:clamp(2.7rem,5vw,4.7rem);margin:12px 0 18px}.hormone-primer-header>p:last-child{font-size:1rem;color:var(--muted);max-width:700px;margin-bottom:0}.hormone-jump{display:flex;flex-wrap:wrap;gap:10px 25px;border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:17px 0;margin-bottom:28px}.hormone-jump a{display:flex;align-items:center;gap:9px;font-size:1rem;line-height:1.5;color:var(--blue)}.hormone-jump a span{font-size:.8125rem;color:var(--muted);font-variant-numeric:tabular-nums}.hormone-jump a:hover{text-decoration:underline;text-underline-offset:4px}.hormone-basics{display:grid;grid-template-columns:1fr 1fr;gap:32px;font-size:1rem;line-height:1.65;padding-bottom:12px}.hormone-basics p{margin:0 0 20px}.hormone-basics strong{display:block;color:var(--ink);margin-bottom:9px;font-weight:600}.hormone-entry{display:grid;grid-template-columns:minmax(0,1fr) minmax(270px,350px);gap:50px;padding:38px 0 42px;border-top:1px solid var(--line);scroll-margin-top:26px}.hormone-entry-meta{display:flex;gap:14px;align-items:center;font-size:.875rem;color:var(--muted);margin-bottom:14px}.hormone-entry-meta>span:first-child{font-variant-numeric:tabular-nums;color:var(--blue)}.hormone-copy h2{font-family:'Instrument Serif',Georgia,serif;font-size:2.85rem;line-height:1.05;margin:0 0 8px;font-weight:400}.hormone-full-name{color:var(--muted);font-size:1rem;margin:0 0 20px}.hormone-copy h3{font-size:.9375rem;font-weight:650;margin:20px 0 7px}.hormone-copy p{font-size:1rem;line-height:1.65}.hormone-copy .hormone-origin{font-size:.9375rem;color:var(--muted);padding-bottom:16px;margin-bottom:0;border-bottom:1px solid var(--line)}.hormone-origin strong{font-weight:500;color:var(--ink)}.hormone-copy .hormone-caveat{font-size:.9375rem;color:var(--muted);border-left:2px solid #b8c5de;padding-left:14px}.hormone-reading{display:flex;flex-wrap:wrap;gap:9px 18px}.hormone-reading a{font-size:.875rem;color:var(--blue);line-height:1.5;text-decoration:underline;text-underline-offset:3px}.hormone-reading svg{width:13px;height:13px;display:inline;vertical-align:middle}.hormone-figure{margin:0;align-self:start;background:#fff;border:1px solid var(--line);border-radius:14px;overflow:hidden}.hormone-model-stage{width:100%;min-height:245px;background:linear-gradient(145deg,#f2f6ff,#fff);touch-action:pan-y;cursor:grab}.hormone-model-stage.is-dragging{cursor:grabbing}.hormone-molecule{width:100%;height:auto;display:block;user-select:none}.hormone-molecule text{font-family:'DM Sans',system-ui,sans-serif;font-size:12px;font-weight:650;fill:#455672}.hormone-figure figcaption{padding:0 20px 12px}.hormone-figure figcaption strong{font-size:.9375rem;font-weight:500}.hormone-figure figcaption strong span{color:var(--muted);padding:0 3px}.hormone-figure figcaption p{font-size:.875rem;color:var(--muted);line-height:1.5;margin:8px 0 0}.hormone-model-controls{padding:0 20px 20px}.hormone-model-controls>span{font-size:.8125rem;display:block;color:var(--muted);margin:0 0 10px}.hormone-model-controls>div{display:flex;flex-wrap:wrap;gap:8px}.hormone-model-controls button{font-size:.875rem;padding:8px 10px;min-height:38px;background:#fff;border:1px solid var(--line);border-radius:6px}.hormone-model-controls button:hover{background:var(--soft);border-color:#aabfe9}.hormone-structure-details{padding:16px 20px;border-top:1px solid var(--line);font-size:.875rem;color:var(--muted);line-height:1.65}.hormone-structure-details summary{cursor:pointer;color:var(--ink);font-size:.875rem}.hormone-structure-details p{margin:12px 0}.hormone-structure-details a{color:var(--blue);text-decoration:underline;text-underline-offset:3px}.hormone-structure-details svg{width:13px;height:13px;display:inline;vertical-align:middle}.hormone-primer-footer{border-top:1px solid var(--line);padding:25px 0 15px;font-size:.875rem;color:var(--muted)}.hormone-primer-footer>div{display:flex;flex-wrap:wrap;gap:24px;margin-top:24px}
@media(max-width:1050px){.hormone-entry{gap:28px;grid-template-columns:minmax(0,1fr) minmax(240px,300px)}}
@media(max-width:700px){.hormone-primer-teaser{display:block;padding:22px}.primer-link-label{margin-top:16px}.hormone-basics{grid-template-columns:1fr;gap:0}.hormone-entry{grid-template-columns:1fr;gap:24px;padding:30px 0}.hormone-figure{width:100%;max-width:380px;justify-self:center}.hormone-primer-header{margin-top:26px}.hormone-jump{gap:12px 20px}.hormone-copy h2{font-size:2.55rem}}
@media print{.hormone-model-controls{display:none!important}.hormone-entry{break-inside:avoid}.hormone-model-stage{background:#fff}}

/* Cholesterol pathway primer: a shared map, followed by class-specific biology and safety. */
.mechanism-primer{max-width:1120px;margin:auto;font-size:1rem;line-height:1.65}
.mechanism-header{max-width:850px;margin:30px 0}.mechanism-header h1{font:400 clamp(2.6rem,4.5vw,4rem)/1.06 'Instrument Serif',Georgia,serif;margin:12px 0 20px}.mechanism-header>p{font-size:1.125rem;color:var(--muted);max-width:700px}
.mechanism-overview{border:1px solid var(--line);border-radius:14px;overflow:hidden;margin:30px 0}.mechanism-map-heading{display:flex;align-items:baseline;justify-content:space-between;gap:20px;padding:24px 26px 12px}.mechanism-map-heading h2{font-size:1.15rem;margin:0}.mechanism-map-heading p{font-size:.875rem;color:var(--muted);margin:0}.mechanism-select{display:flex;flex-wrap:wrap;gap:8px;padding:0 26px 22px}.mechanism-select button{font:inherit;font-size:.9375rem;line-height:1.4;padding:10px 14px;border:1px solid var(--line);border-radius:7px;color:var(--ink);background:#fff;cursor:pointer}.mechanism-select button[aria-pressed=true]{color:#fff;background:var(--blue);border-color:var(--blue)}.mechanism-select button:hover{border-color:var(--blue)}
.mechanism-flow{display:grid;grid-template-columns:minmax(0,1fr) 74px minmax(0,1.35fr) 74px minmax(0,1fr);align-items:center;padding:14px 26px 24px;background:#f5f8fd;gap:8px}.mechanism-organ{border:1px solid #cbd6e8;border-radius:9px;min-width:0;padding:20px 14px;background:white;text-align:center}.mechanism-organ.is-active{border:2px solid var(--blue);padding:19px 13px;box-shadow:0 0 0 3px #e4ebff}.mechanism-site-label{font-size:.875rem;color:var(--muted)}.mechanism-organ h3{font:400 1.75rem/1.15 'Instrument Serif',Georgia,serif;margin:11px 0 13px}.mechanism-organ p{font-size:.9375rem;line-height:1.55;margin:0 0 15px}.mechanism-target{display:block;font-size:.875rem;line-height:1.5;color:var(--muted);border-top:1px solid var(--line);padding-top:12px}.mechanism-liver-targets{display:grid;gap:6px;font-size:.875rem;line-height:1.5}.mechanism-liver-targets>span{padding:8px 4px;background:#f3f6fb;border-radius:5px}.mechanism-liver-targets>span.is-active{background:#e7edff;color:#214ba8}.mechanism-flow-arrow{display:flex;flex-direction:column;align-items:center;gap:8px;color:#496080;text-align:center;font-size:.875rem;line-height:1.45}.mechanism-flow-arrow svg{width:38px;height:25px}.mechanism-uptake svg{transform:rotate(180deg);order:2}
.mechanism-selection{display:flex;align-items:center;gap:26px;justify-content:space-between;padding:22px 26px;background:#13316a;color:#fff;min-height:192px}.mechanism-selection .eyebrow{color:#c4d5fc;font-size:.875rem}.mechanism-selection h3{font-size:1.15rem;font-weight:500;line-height:1.4;margin:10px 0}.mechanism-selection p{font-size:1rem;color:#e0e9fb;margin:0;max-width:700px}.mechanism-selection>a{font-size:.9375rem;line-height:1.5;flex:0 0 160px;display:flex;gap:10px;align-items:center;color:#fff;text-decoration:underline;text-underline-offset:3px}.mechanism-selection>a svg{width:20px;flex:none}.mechanism-map-note{font-size:.875rem;color:var(--muted);padding:16px 26px;margin:0}
.mechanism-safety-intro{padding:4px 0 24px;max-width:900px}.mechanism-safety-intro h2{font-size:1.15rem;margin:0 0 14px}.mechanism-safety-intro p{font-size:1rem;color:var(--muted);margin:0 0 12px}
.mechanism-entry{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:30px 46px;border-top:1px solid var(--line);padding:40px 0;scroll-margin-top:26px}.mechanism-copy h2{font:400 2.75rem/1.08 'Instrument Serif',Georgia,serif;margin:0 0 10px}.mechanism-family{font-size:.9375rem;color:var(--muted);margin-bottom:25px}.mechanism-copy h3{font-size:1rem;margin:22px 0 7px}.mechanism-copy p{margin-top:0}.mechanism-distinction{border-left:2px solid #b8c5de;padding-left:16px;color:var(--muted)}.mechanism-therapy-links{display:flex;flex-wrap:wrap;gap:10px 20px;margin-top:26px;font-size:.875rem}.mechanism-therapy-links>span{width:100%;color:var(--muted)}.mechanism-therapy-links a{color:var(--blue);text-decoration:underline;text-underline-offset:3px}.mechanism-therapy-links svg{width:13px;display:inline;vertical-align:middle}
.mechanism-safety{align-self:start;background:#f5f7fb;border:1px solid var(--line);border-radius:10px;padding:24px}.mechanism-safety h3{font-size:1.1rem;margin:0 0 13px}.mechanism-safety h4{font-size:.9375rem;margin:20px 0 8px}.mechanism-safety p{font-size:1rem;margin:0 0 13px}.mechanism-important{padding:1px 0 0;border-top:1px solid var(--line);margin-top:20px}.mechanism-safety details{border-top:1px solid var(--line);margin-top:20px;padding-top:16px}.mechanism-safety summary{font-size:.9375rem;cursor:pointer;font-weight:500}.mechanism-safety details p{font-size:.9375rem;margin-top:14px}.mechanism-safety .mechanism-rate-note{font-size:.875rem;color:var(--muted)}.mechanism-entry-sources{grid-column:1/-1;display:flex;align-items:baseline;gap:18px;font-size:.875rem;color:var(--muted)}.mechanism-entry-sources>span{flex:none}.mechanism-entry-sources .hormone-reading{gap:8px 18px}
.mechanism-evidence{border-top:1px solid var(--line);padding:32px 0 12px}.mechanism-evidence h2{font:400 2.25rem/1.1 'Instrument Serif',Georgia,serif;margin:0 0 20px}.mechanism-evidence>p{max-width:850px}.mechanism-evidence>div{display:flex;flex-wrap:wrap;gap:20px 35px;margin:24px 0}.mechanism-evidence .mechanism-scope{font-size:.875rem;color:var(--muted);margin-top:30px}.mechanism-context-links{font-size:.9375rem;margin:20px 0}.mechanism-context-links a{color:var(--blue);text-decoration:underline;text-underline-offset:3px}.mechanism-context-links>span{color:var(--muted)}
@media(max-width:1100px){.mechanism-flow{grid-template-columns:minmax(0,1fr) 60px minmax(0,1.2fr) 60px minmax(0,1fr);padding:16px}.mechanism-organ{padding:16px 10px}.mechanism-organ.is-active{padding:15px 9px}.mechanism-entry{gap:26px}.mechanism-organ h3{font-size:1.5rem}}
@media(max-width:760px){.mechanism-map-heading{display:block;padding:22px 20px 12px}.mechanism-map-heading p{margin-top:7px}.mechanism-select{padding:0 20px 18px}.mechanism-flow{grid-template-columns:1fr;gap:14px;padding:22px}.mechanism-organ{padding:19px}.mechanism-organ.is-active{padding:18px}.mechanism-organ p br{display:none}.mechanism-flow-arrow{flex-direction:row;justify-content:center}.mechanism-flow-arrow svg{transform:rotate(90deg);width:28px}.mechanism-flow-arrow span br{display:none}.mechanism-uptake svg{transform:rotate(-90deg);order:0}.mechanism-selection{display:block;padding:22px;min-height:0}.mechanism-selection>a{margin-top:20px}.mechanism-map-note{padding:18px 22px}.mechanism-liver-targets{grid-template-columns:1fr 1fr}.mechanism-entry{grid-template-columns:1fr;gap:24px;padding:30px 0}.mechanism-entry-sources{display:block}.mechanism-entry-sources>span{display:block;margin-bottom:10px}.mechanism-copy h2{font-size:2.35rem}.mechanism-safety{padding:22px}.mechanism-header h1{font-size:2.8rem}}
@media print{.mechanism-entry{display:block}.mechanism-safety{margin:20px 0}.mechanism-entry-sources{margin-bottom:20px}.mechanism-select{display:none}}

/* Immediate curve identity, scoped to weight-loss plots (including their dialog). */
.weight-curve-frame{position:relative;isolation:isolate}
.weight-curve-tooltip{position:absolute;z-index:3;pointer-events:none;max-width:min(320px,calc(100% - 16px));padding:12px 15px;background:#fff;border:1px solid var(--line);border-left:3px solid var(--point-color);border-radius:9px;box-shadow:0 5px 22px #18263c1a;color:var(--ink);font-size:.83rem;line-height:1.55}
.weight-curve-tooltip[hidden]{display:none}.weight-curve-tooltip strong{display:block;font-size:.96rem;font-weight:650}.weight-curve-tooltip span{display:block;color:var(--muted);margin-top:3px}.weight-curve-tooltip span[hidden]{display:none}.weight-curve-tooltip [data-curve-visit]{color:var(--ink);border-top:1px solid var(--line);margin-top:8px;padding-top:7px}
.weight-curve-frame.is-identifying .weight-curve{opacity:.22}.weight-curve-frame.is-identifying .weight-curve.is-highlighted{opacity:1}.weight-curve-frame .weight-curve.is-highlighted .weight-curve-line{stroke-width:4.5}
@media print{.weight-curve-tooltip{display:none!important}.weight-curve-frame.is-identifying .weight-curve{opacity:1}}

.lipid-detail>.weight-history{margin:20px 0}

/* Leave breathing room when following a specific finding from Latest Signals. */
.prose :is(h3,h4,h5,h6)[id],.note-anchor{scroll-margin-top:2rem}
.note-anchor{display:block}